PROSTATE CANCER

Prostate cancer etiology and risk factors People suffering from prostate cancer remained unknown. However, there are some factors on the development of prostate cancer play a role i...

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Low income families, was born in the rural areas, smoking, alcohol, divorce (widowed), regular milk, eggs and eat pork, residents of China is suffering from prostate cancer risk factors and eat more green vegetables, fruits and legumes food is important protective factors; Residents of China on prostate cancer prevention should adopt a diet consisting mainly of behavioral intervention and comprehensive measures. This is the Tongji Medical College of Huazhong University of Science and Technology Department of Epidemiology Professor Shi Lu, a recently completed research projects concluded.

Residents of prostate cancer incidence is lower than abroad, but with the aging of China's population and the improvement of people's living standards, the incidence of the disease growing trend, prostate cancer etiology and crowd control system study has not yet been carried out. In 1996, Professor Shi Lu, who assumed the Ministry of Health funded research project "related to prostate cancer epidemiology and genetics research," in Wuhan City residents prostate cancer and distribution of popular trends on the basis of the study, through document retrieval and review, a comprehensive understanding of prostate cancer because of on the status quo and a hospital-based frequency matched case-control study was conducted extensive survey of risk factors, and to explore its pathogenesis.

The study surveyed by the organization pathology or cytology diagnosis of prostate cancer patients 149 cases, 196 cases with the election control, according to design requirements of their economic status, personal living habits (such as smoking, drinking, leisure time physical activity habits), vocational and occupational categories the history of contact with poison, personal medical history and family history of the disease, marriage and fertility status, eating habits and frequency, height and weight, and other investigations. The non-conditional logistic regression analysis of these factors and prostate cancer, the results indicate that low-income families, was born in the rural areas, smoking, alcohol, divorce (or widowed), and drink milk, eat eggs and pork prostate cancer is the major risk factors, smoking, drinking, drinking milk three factors in the pathogenesis of prostate cancer were synergistic (Additive or synergistic), and eat green vegetables, fruits and legumes food is important protective factors.

The incidence of prostate cancer in the study, the researchers used Northern blot to detect prostate cancer tissues oncogene c-erbB-2 and p53 tumor suppressor gene expression results showed that p53 in prostate cancer and development may have important biological effects; Using PCR-denaturing polyacrylamide gel electrophoresis and silver nitrate staining techniques, prostate cancer chromosome 8p22 - p12 regional sites for allele specific hybridization analysis of the loss, suggesting that the region 8p22 - p12 allele-specific hybridization - point loss and the incidence of prostate cancer and development closely related. They also used Immunocytochemistry technology, detection of prostate cancer tissue proliferation of insulin-like growth factor - I receptor and vascular endothelial growth factor expression and the distribution of insulin-like growth factor that - I receptor and vascular endothelial growth factor in the development of prostate cancer or may have an important role.

Relevant experts believe that the study for a comprehensive understanding of China's residents prostate cancer risk factors and the occurrence and development of the molecular genetics and cell biology of important theoretical and practical value, and recommended further expansion of samples, a multiple comparison of prostate cancer-related gene cancer in the process of significance for more detailed study.

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