New safety in the use and pancreatic cancer vaccine-induced immune response
Earlier studies showed that pancreatic cancer vaccine safe and effective Johns Hopkins University School of Medicine study of 14 patients with pancreatic cancer vaccine experiment. Pancreatic cancer surgery remov...
Combination of radiotherapy and chemotherapy in patients with advanced pancreatic cancer will regain hope surgery The University of Michigan Medical School and his colleagues, Dr. JB Ammori that radiotherapy combined gemcitabine (Gem / RT) as a new mean...
Baltimore, Johns Hopkins Medical Association's Dr. Elizabeth M. Jaffee and his colleagues on the 14 cases eight weeks before the trip Pancreatoduodenectomy pancreatic adenocarcinoma patients given various doses of allogeneic secreted GM-CSF (granulocyte-macrophage colony-stimulating factor) of the tumor vaccine Test.
12 cases of patients tested with the vaccine after a six-month adjuvant radiotherapy and chemotherapy. Such treatment after six cases in remission after one month by month by month to give three times the original dose immunization.
Study found no toxicity. Furthermore, the acceptance of 100 million or more cells in the vaccine three cases of patients with autologous tumor cells delayed-type hypersensitivity. Researchers said that the three cases will be no extension of survival time, tumor survival after diagnosis of at least 25 months.
Dr. Jaffee said three cases of immune responses in patients with the diagnosis of no more than three years of survival. Although researchers have also not convinced that the response is caused by vaccines, but these results are sufficient to carry out a large-scale study.
As for the vaccine in patients with non-response, Dr. Jaffee speculate, may be non-vaccine itself can activate the immune system in such a proper protein. But according to other means of detection, Dr. Jaffee stressed that the respondents do not have a better immune system and the patient's age is not factor.
Dr. Jaffee said, in the future will not only study of the vaccine after role, and low-dose chemotherapy and the use of the vaccine on the role of metastatic tumor. The animal model showed small dose of the vaccine can boost the effectiveness of Taxol.
Dr. Jaffee said, similar to the existing research involving 60 patients in the study is expected after two to three months, while one pair of the more advanced tumors with chemotherapy and vaccine research to be implemented.
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