Earlier studies showed that pancreatic cancer vaccine safe and effective
New safety in the use and pancreatic cancer vaccine-induced immune response Baltimore, Johns Hopkins Medical Association's Dr. Elizabeth M. Jaffee and his colleagues on the 14 cases eight weeks before the trip P...
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Johns Hopkins University School of Medicine study of 14 patients with pancreatic cancer vaccine experiment. Pancreatic cancer surgery removed the tumor, 14 patients received different doses of the vaccine. Research found that the largest dose of the vaccine in patients with the three parts of the immune system is activated in the diagnosis after 30 months without recurrence symptoms, and 11 were no obvious response. After vaccination side effects of the injection site within a few days localized skin reaction, redness, itching and so on.
The leadership of the Clinical Oncology, Doctor of Medicine, Professor Elizabeth Jefferson said: "This study is only the first step. But we found that the vaccine is safe, but after reaching a certain dose really immune response. Results have been encouraging. "
Researchers will join the GM-CSF gene pancreatic cancer cells acquire such vaccines. GM-CSF gene activation of the immune system is the most effective gene, it can attract immune cells to the surface antigen accumulation of the tumor cells. These antigen in the immune system can identify and guide the residual damage in patients in other locations of cancer.
Jefferson said: "If these transgenic vaccine can be used to help eradicate surgery, chemotherapy and radiotherapy after residual cancer cells. We need to find the best combination of treatments, to provide patients with the greatest chance of survival. "
But the researchers also said, to the ultimate test the effectiveness of the vaccine also require in-depth study and assessment. Johns Hopkins University will begin in the summer of 2001 for the second phase of the vaccine experiment.
According to statistics, the United States every year about 28,000 people died of pancreatic cancer, no more than 5% of the pancreatic cancer patients can live more than five years.
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