PROSTATE CANCER

Urological Institute Europe (EAU) in the first prostate cancer treatment guidelines published in 2001. In the past few years, whenever affect prostate cancer (CaP) clinical treatment of the important changes, EAU Guide will be updated. In August 2005, EAU again updated the prostate cancer treatment guidelines. From www.uroweb.org new website will be a complete version of the Guide.

Prostate cancer - healthy elderly men occult killer <BR> Zhao After various inspections, the results, he appeared prostate cancer patients with bone metastasis. That is prostate cancer the cancer had metastasized to the bone, the bone caused pain and lead to a strong movement disorders.
Prostate cancer is the world's sixth largest malignancy. In the United States, the incidence rate of prostate cancer, a malignancy Habitat men, second only to lung cancer mortality, accounting for second place, each six older Americans out of a person suffering from prostate cancer. With the aging of our population, the incidence of prostate cancer is increasing year by year, its impact on the health of older men are increasingly apparent. Shanghai, the incidence of prostate cancer in 1985 was 2.6/10 10,000 by the year 2000 increased to 7.7/10 million, is expected in 2005 will reach 10/10 10,000. Similar to the situation in Beijing, in 1985 the incidence rate was 2. 38/16 10000, 1985 ~ 1995, the City of prostate cancer incidence increased by 2.3 times, is also expected to achieve a 10/10 10,000.
Bone metastases of prostate cancer is the main performance <BR> advanced prostate cancer is the most vulnerable to the malignant bone metastasis, more than 80% of patients with prostate cancer bone metastases will happen. Metastatic bone lesions can be found at Ilium, vertebrae, ribs, skull and proximal long bones, mostly in the avascular bone axis rich site. The most common prostate cancer is the first clinical manifestation of bone metastasis is the bone pain. Sustained pain, and often affect patients with anorexia and daily rhythm of life, so patients increasingly emaciated, the misery. Secondly, because the bones were 1.1 points to tumor cells "eat", the bone metastasis was prone to pathologic fracture. If tumor cells of the patient spinal vertebrae, then vertebral collapse will lead to the symptoms of spinal cord compression by, it makes treatment more difficult.
Bone metastases of prostate cancer treatment is a comprehensive treatment of early prostate cancer often <BR> male androgen treatment resistance is sensitive. But with the development of disease, treatment of androgen resistance will gradually lose their role, but also the development of prostate cancer has advanced. Fortunately, the disease Although Zhao advanced prostate cancer, but resistance to androgen therapy is sensitive. Through oral drugs and the necessary surgical intervention, he fell to a certain androgen levels. In order to alleviate the symptoms of bone pain, the doctors gave him a main component of the use of bisphosphonates for the special drug. With drug drop by drop in the importation of Mr. Zhao, bone pain from the torture he gone step by step, gradually smile in the face of Mr. Zhao spacious. Three weeks later, Mr. Zhao calmly walked out the door of the hospital.
Bone metastases of prostate cancer treatment in addition to the above-mentioned endocrine therapy (androgen treatment resistance), bisphosphonates in the treatment, under different conditions also can be used chemotherapy, the radiation therapy, radiation therapy within radionuclide therapy and various integrated applications. Another more advanced treatment, such as immune therapy and gene therapy, is still in the pilot stage, clinical application of small, but has a very broad application prospects.
Urology doctors Suggestions <BR> majority of prostate cancer patients with bone metastasis, because of a certain feeling of headaches body to the hospital and found the orthopedic treatment. But unfortunately, at this time of prostate cancer has developed to the advanced. Therefore, the importance of early detection of prostate cancer.
The generally accepted clinical effective early detection of prostate cancer is the digital rectal examination and examination of the serum concentration of P SA. Digital rectal examination can be found in prostate cancer nodules, carefully rectal examination for prostate cancer early diagnosis and staging are of important significance. If that is found suspicious nodules, it would need to further prostate biopsy, about 70% of the patients could be diagnosed. PSA is a prostate cancer-specific serum indicators, generally less than normal abnormal. If higher than the target, this will cause doctors attention. Men over the age of 45, preferably every three months to six months to see a urology clinic, do a detailed inspection of prostate related.

Treatment of prostate cancer patients with life expectancy and social relations, family and economic situation correspond to the current surgery and radiotherapy only hope to cure prostate cancer, but only a small number of patients suitable for both therapy. Many palliative therapy only, can ease symptoms, but the patient will not have an impact on survival. Therefore, treatment should be integrated in all aspects, the development of rational treatment programs. Current clinical treatment methods used as follows:

1. Endocrine therapy of prostate cancer with typical hormone-dependent, in clinical endocrine treatment of prostate lesions and can significantly ease symptoms, but with no obvious impact on survival.

Prostate cancer is common urological cancer, early often asymptomatic, most of the patients when treatment is already advanced. Some patients because of distant metastases, traced search for the source of prostate cancer at diagnosis. The treatment of prostate cancer is still a radical resection of the prostate, endocrine therapy and radiotherapy. For the treatment of advanced prostate cancer, hormonal therapy and that radiation therapy is the most effective means. Common methods for testicular castration operation, anti - androgen drugs such as flutamide, a KANG Shi.

Endocrine therapy for the treatment of early prostate cancer satisfied with the results, but with the passage of time, transformed into a prostate cancer - androgen-independent cells, a PSA rise, affecting endocrine therapy. Radiation therapy is the treatment of advanced prostate cancer effective method, interference radiation on DNA synthesis, can effectively kill tumor cells, reduce infiltration around the tumor and lower. Apart from the radiation therapy, radiation particles implant brachytherapy, in recent years the rapid development of new technologies, the effect of high-low complication of normal tissues to radiation damage to the minimum extent. Particulate radiation brachytherapy implant can be used in early and advanced prostate cancer.

Prostate cancer brachytherapy method is the basic specifications of a certain number of sources directly inserted into the prostate, prostate cancer cells to high doses. In order to be satisfied with the treatment site dose, must formulate specific preoperative treatment planning system, according to sources around the dose distribution of the rules with a certain amount of these radioactive sources. Prostate cancer radiation therapy using CT, MRI and other imaging computer 3D reconstruction of the pool cloth reasonable and reliable. Through tablets tablets source of activity and spacing adjustment to the target dose uniformity, the target dose of a sudden drop, which will help protect normal tissue. Using the short half-life of radioactive nuclides, to kill or inhibit the proliferation of fast tumor cells more favorable. Treatment is simple, injury, protective security, and other benefits. Current prostate brachytherapy treatment of multiple choice I Pa 103 or 125.

Two Zhejiang Medical Center urology in the province in the first brachytherapy treatment of prostate cancer, nearly five years for a total of 100 cases of prostate cancer, including many other cases of failure, through our years of observation, patients with most cases PSA values decreased significantly, and prostate cancer mass was soft, small change, no serious complications in patients with prolonged survival time and improve the quality of life. Through clinical analysis, we believe that brachytherapy treatment of brachytherapy treatment of prostate cancer is an effective alternative method.